Package: crmPack
License: GPL (>= 2)
Title: Object-Oriented Implementation of CRM Designs
LazyLoad: yes
Authors@R: c(
  person("Daniel", "Sabanes Bove", email = "daniel.sabanes_bove@rconis.com", role = c("aut", "cre")),
  person("Wai", "Yin Yeung", email = "winnie.yeung@roche.com", role = c("aut")),
  person("Giuseppe", "Palermo", email = "giuseppe.palermo@roche.com", role = c("aut")),
  person("Thomas", "Jaki", email = "jaki.thomas@gmail.com", role = c("aut")))
Description: Implements a wide range of model-based dose
    escalation designs, ranging from classical and modern continual
    reassessment methods (CRMs) based on dose-limiting toxicity endpoints to
    dual-endpoint designs taking into account a biomarker/efficacy outcome. The
    focus is on Bayesian inference, making it very easy to setup a new design
    with its own JAGS code. However, it is also possible to implement 3+3
    designs for comparison or models with non-Bayesian estimation. The whole
    package is written in a modular form in the S4 class system, making it very
    flexible for adaptation to new models, escalation or stopping rules.
Version: 1.0.6
Copyright: F. Hoffmann-La Roche Ltd
URL: https://github.com/openpharma/crmPack
BugReports: https://github.com/openpharma/crmPack/issues
VignetteBuilder: knitr
Depends: R (>= 3.0.0), ggplot2 (>= 2.0.0), graphics
Imports: methods, grid, gridExtra, GenSA, mvtnorm, parallel, rjags,
        utils, tools, MASS
Suggests: ggmcmc, knitr, Rcpp, RcppArmadillo
Collate: 'helpers.R' 'Data-class.R' 'Data-methods.R' 'Rules-class.R'
        'Model-class.R' 'Design-class.R' 'writeModel.R'
        'McmcOptions-methods.R' 'McmcOptions-class.R' 'Samples-class.R'
        'mcmc.R' 'Simulations-class.R' 'Model-methods.R'
        'Rules-methods.R' 'Design-methods.R' 'fromQuantiles.R'
        'Samples-methods.R' 'Simulations-methods.R' 'crmPack-package.R'
RoxygenNote: 7.2.1
Encoding: UTF-8
NeedsCompilation: no
Packaged: 2024-06-26 14:04:16 UTC; sabanesd
Author: Daniel Sabanes Bove [aut, cre],
  Wai Yin Yeung [aut],
  Giuseppe Palermo [aut],
  Thomas Jaki [aut]
Maintainer: Daniel Sabanes Bove <daniel.sabanes_bove@rconis.com>
Repository: CRAN
Date/Publication: 2024-06-26 15:00:14 UTC
Built: R 4.6.0; ; 2025-10-14 02:21:00 UTC; windows
